Science.

The beauty and diversity of nature is encoded within the genome. With the advent of genome sequencing, we can read this information, and understand how nature is organised and expressed through genes.

With advances in DNA synthesis and genome engineering, we can design and write new genomes not otherwise found in nature.

Research in our laboratory is focused on using NGS to analyse genes, and DNA synthesis to assemble genes. We use genomic, bioinformatic and synthetic biology methods, as well as creativity and imagination, to build genes tailored to solve complex problems in health care, industry and agriculture.

Approach.

Our studio couples the reading and writing of read of genes, we can accelerate the design, testing and translation of genomics;

READ. We use long-read, real-time, adaptive Oxford Nanopore sequencing to resolve the complexity of the genome, and the expression of the transcriptome.

DESIGN. We use high-performance computation to design new genes and genomes tailored according to precise and custom requirements.

WRITE. We are part of the BASE facility facility that hosts advanced equipment (inc. DNAscript Syntax for enzymatic nucleotide synthesis) and skilled scientists able to deliver genomes according to design.

Applications.

GENE SPLICING. The information encoded within genome is expressed as complex spliced RNA isoforms. Understanding how a gene is spliced and expressed allows us to understand the grammar by which genome information is organised. Accordingly, we study the natural and synthetic splicing of genes.

CLINICAL GENOMICS. Genome sequencing can identify the mutations that cause diseases such as cancer. However, clinical diagnosis requires that genome sequencing is accurate and reliable. We develop synthetic RNA and DNA controls (sequins) that are used to improve the accuracy of clinical genome sequencing.

SYNTHETIC BIOLOGY. Our studio designs and assembles novel genes that are tailored to address challenges in health and industry. We have built synthetic genomes for use in genomics, transcriptomics and proteomic applications.